LYMPHOID NEOPLASIA Molecular features of hepatosplenic T-cell lymphoma unravels potential novel therapeutic targets
نویسندگان
چکیده
1Inserm U955, Créteil, France; 2Université Paris-Est, Créteil, France; 3Département de Pathologie, Assistance Publique des Hôpitaux de Paris (AP-HP), Groupe Henri-Mondor Albert-Chenevier, Créteil, France; 4Department of Anatomic Pathology, Chang Gung Memorial Hospital and Department of Pathology, Chang Gung University, Gueishan, Taiwan; 5Institute of Pathology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland; 6Service d’Immunologie Biologique, AP-HP, Créteil, France; 7Departement de Pathologie, Hôpital Lyon-Sud, Pierre-Benite, France; 8Department of Medical Biology and Pathology, Institut Gustave Roussy, Villejuif, France; 9Inserm U728 et Service de Pathologie, Hôpital Saint Louis, Paris, France; 10Inserm U976, Hôpital Saint Louis, Paris, France; 11Hématologie, AP-HP Hôpital Necker-Enfants-Malades and Université Paris Descartes, Paris, France; 12Department of Histopathology, University College Hospital London, London, United Kingdom; and 13Ligue Nationale Contre le Cancer, Paris, France
منابع مشابه
Molecular features of hepatosplenic T-cell lymphoma unravels potential novel therapeutic targets.
The pathogenesis of hepatosplenic T-cell lymphoma (HSTL), a rare entity mostly derived from γδ T cells and usually with a fatal outcome, remains largely unknown. In this study, HSTL samples (7γδ and 2αβ) and the DERL2 HSTL cell line were subjected to combined gene-expression profiling and array-based comparative genomic hybridization. Compared with other T-cell lymphomas, HSTL had a distinct mo...
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Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of lymphoid neoplasms characterized by aggressive clinical behavior and dismal prognosis. Hepatosplenic γδ T-cell lymphoma (γδ-HSTL) is a particular form of PTCL that arises from a small subset of γ/δ T-cell receptor-expressing lymphocytes. γδ-HSTL has a rapidly progressive course and poor outcome due also to its refractoriness to co...
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We conducted comprehensive gene expression profiling (GEP) of primary pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma (n 33) and compared the results to GEP of other Band T-cell lymphomas and normal lymphocytes to identify novel markers and deregulated pathways. MALT has a prominent T-cell signature and a marginal zone/memory B-cell profile. Four novel transcripts were specifically ...
متن کاملGene expression profiling of pulmonary mucosa-associated lymphoid tissue lymphoma identifies new biologic insights with potential diagnostic and therapeutic applications.
We conducted comprehensive gene expression profiling (GEP) of primary pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma (n = 33) and compared the results to GEP of other B- and T-cell lymphomas and normal lymphocytes to identify novel markers and deregulated pathways. MALT has a prominent T-cell signature and a marginal zone/memory B-cell profile. Four novel transcripts were specifica...
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Hepatosplenic T cell lymphoma (HSTCL) is a distinct and lethal subtype of peripheral T cell lymphoma with an aggressive course and poor outcome despite multiagent chemotherapy. Contradictory literature, an unknown etiology, and poor response to treatment highlight the need to define the malignant process and identify molecular targets with potential for successful therapeutic interventions. Her...
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